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|[[Kega Fusion]]
|align=left|{{Icon|Windows|Linux|macOS}}
|[http://www.carpeludum.com/kega-fusion 3.64]
|{{~}}<ref group=N name=kegaCD>While it supports Sega CD emulation, there is notable audio sync issues. Kega is not recommended for CD emulation.</ref> ||{{✓}} ||{{✓}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✓}}
|-
|[http://segaretro.org/Gens/GS Gens/GS]
|align=left|{{Icon|Windows|Linux|macOS|FreeBSD}}
|[http://www.dusers.drexel.edu/gitweb/gitweb.cgi/~korth/gens.git r7]
|{{✓}} ||{{✓}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✗}}
|-
|[[GENS]]
|align=left|{{Icon|Windows|Linux|BeOS}}
|[http://gens.me/downloads.shtml 2.14]
|{{✓}} ||{{✓}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✗}}
|-
|[[higan]]
|align=left|{{Icon|Windows|Linux|macOS|FreeBSD}}
|[https://github.com/higan-emu/higan/releases {{higanVer}}]
|{{~}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✗}}
|-
|AloneMD
|align=left|{{Icon|Windows}}
|[https://standalones.dev 1.0.2]
|{{✓}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✓}} ||?
→Emulators
|[https://buildbot.libretro.com/nightly/ libretro core]
|{{✓}} ||{{✗}}[https://github.com/ekeeke/Genesis-Plus-GX/issues/64 *] ||{{✗}} ||{{✓}} <ref group=N name=libretroonly>On some platforms, this emulator is ''only'' available as a [https://buildbot.libretro.com/nightly/windows/x86_64/latest/ libretro core]. </ref> ||{{✗}} <ref group=N name=noncomm>Due to using a [[Licensing#Non-commercial licenses|non-commercial license]]. Source code is still publicly available.</ref> ||{{✓}} ||{{✓}}
|-
|[[PicoDrive]]
|[https://github.com/ares-emulator/ares/releases {{aresVer}}]
|{{✓}}<ref group=N name=aresCD>[https://old.reddit.com/r/emulation/comments/xs5tol/ares_v130_released_multi_system_cross_platform/iqmia3y/ Needs firmware v2.00, there are issues using older versions.] </ref> ||{{✓}} ||{{✗}}[https://github.com/ares-emulator/ares/issues/833 *] ||{{✗}}||{{✓}}||{{✓}}||{{✓}}
|-
|[[Kega Fusion]]
|align=left|{{Icon|Windows|Linux|macOS}}
|[http://www.carpeludum.com/kega-fusion 3.64]
|{{~}}<ref group=N name=kegaCD>While it supports Sega CD emulation, there is notable audio sync issues. Kega is not recommended for CD emulation.</ref> ||{{✓}} ||{{✓}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{~}}
|-
|[http://segaretro.org/Gens/GS Gens/GS]<br/><small>derived from GENS</small>
|align=left|{{Icon|Windows|Linux|macOS|FreeBSD}}
|[http://www.dusers.drexel.edu/gitweb/gitweb.cgi/~korth/gens.git r7]
|{{✓}} ||{{✓}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{~}}
|-
|[[BizHawk]]
|[http://www.exodusemulator.com/index.php/downloads/current-release {{ExodusVer}}]
|{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✗}}
|-
|[[GENS]]
|align=left|{{Icon|Windows|Linux|BeOS}}
|[http://gens.me/downloads.shtml 2.14]
|{{✓}} ||{{✓}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✗}}
|-
|[[higan]]
|align=left|{{Icon|Windows|Linux|macOS|FreeBSD}}
|[https://github.com/higan-emu/higan/releases {{higanVer}}]
|{{~}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✗}}
|-
|AloneMD
|align=left|{{Icon|Windows}}
|[https://standalones.dev 1.0.2]
|{{✓}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✓}} ||?
|-
|[[FinalBurn Neo]]
|[https://github.com/finalburnneo/FBNeo/releases/latest Stable] <br/>[https://ci.appveyor.com/project/tmaul/fbneo-kbhgd/branch/master WIP builds]
|{{✗}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} <ref group=N name=noncomm /> ||{{✓}} ||{{✗}}
|-
|[http://dgen.sourceforge.net/ DGen]
|[https://segaretro.org/KGen 034b]<br/>[https://segaretro.org/KGen98 9804]
|{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✗}}
|-
|Megado
|[http://aamirm.hacking-cult.org/www/regen.html 0.972]
|{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||? ||{{✗}} ||{{✗}}
|-
!colspan="10"|Mobile / ARM
|align=left|{{Icon|Android|Pandora|Gizmondo|Wiz}}<br/>{{Icon|GP2X}}
|[http://notaz.gp2x.de/pico.php {{PicoDriveVer}}] [https://buildbot.libretro.com/nightly/android/latest/ libretro core]
|{{✓}} ||{{✓}} ||{{✓}} ||{{✓}} <ref group=N name=libretroonly /> ||{{✗✓}} <small>(NDS)</small> <ref group=N name=noncomm /> ||{{✓}} ||{{✓}}
|-
!colspan="10"|Consoles
|-
|[[PicoDrive]]
|align=left|{{Icon|PS2|Wii}}<br/>{{Icon|PSP}}<br/>{{Icon|NDS}}<br/>{{Icon|3DS}}
|[http://notaz.gp2x.de/pico.php {{PicoDriveVer}}]<br/>[https://www.ps2-home.com/forum/viewtopic.php?f=99&t=1710 PicoDrive 1.51b]<br/>[https://retroarch.com/?page=platforms {{RetroArchVer}}]
|{{✓}} ||{{✓}} ||{{✓}} ||{{✓}} ||{{✗✓}} <small>(NDS/3DS)</small> <ref group=N name=noncomm /> ||{{✓}} ||{{✓}}
|-
|[[Virtual Console]]
|[https://digiex.net/threads/sega-genesis-plus-libexnon-genesis-megadrive-emulator-for-xbox-360-download.9936 Libxenon]
|{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||? ||{{✗}} ||{{✗}}
|-
|jEnesisDS
|align=left|{{Icon|NDS}}
|[https://nds.scenebeta.com/noticia/jenesisds]
|{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{✓}}
|}
</div>
;[[BizHawk]]
:"Just works out of the box" solution for Genesis/Mega Drive, CD & 32X, bundled with two cores (Genplus-GX/Genesis Plus GX without [https://github.com/TASEmulators/BizHawk/issues/1528 without Nuked OPN2 support] and PicoDrive), ensuring both excellent compatibility and good speed.
;[[Kega Fusion]]
==Mega Drive Plus / Genesis Plus / MSU-MD modes==
The Mega Drive Plus / Genesis Plus (sometimes abbreviated as MD+) is a special mode for certain Genesis games that use enhanced CDDA tracks with a Sega CD. This was not used in any official games, however, the mode itself was first used in the first batch of Pier Solar releases. This feature was been [https://downloads.terraonion.com/public/MegaSD_DEV_Manual.pdf documented] to be used on Terraonion's Mega SD flash cartridge, to give similar effects for Genesis games in a way how that MSU-1 does in patched SNES games. Another variant was been made for [https://krikzz.com/store/home/59-mega-everdrive-pro.html Mega Everdrive PRO], named [https://github.com/krikzz/msu-md MSU-MD].
Currently, only Genesis Plus GX supports both modes as mentioned [https://github.com/ekeeke/Genesis-Plus-GX/issues/297#issuecomment-918468508 here], while Kega Fusion supports games that can only run in MSU-MD mode.
A variant called 32x Plus (abbreviated as 32x+) made exclusively for Sega 32x games also exist, but again, it is only used by homebrew software, such as ''Doom 32x Resurrection.''
==External links==
