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The Sega CD was released on October 15, 1992 , and retailed for {{Inflation|USD|299.99|1992}} and had a Motorola 68000 CPU at 12.5 MHz and 64 kbit of RAM. The Sega 32X was released on November 21, 1994 for {{Inflation|USD|159.99|1994}}. It had 2 SH-2 RISC CPUs at 23 MHz with 256KB of RAM and 256KB of VRAM.

|{{✓}} ||{{✗}} ||{{✗}} ||{{✓}}* <ref group=N name=libretroonly>On some platforms, this emulator is ''only'' available as a libretro core.</ref> ||{{{✗}} <ref group=N name=noncomm>Due to using a [[Licensing#Non-commercial licenses|non-commercial license]]. Source code is still publicly available.</ref> ||{{✓}} ||{{✓}}

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|[http://www.carpeludum.com/kega-fusion/ 3.64]|{{✓}} ||{{✓}} ||{{✓}} ||{{✗}} ||{{✗}} ||{{✗}} ||{{~✓}}|-|[[ares]]|align=left|{{Icon|Windows|Linux|macOS}}|[https://github.com/ares-emulator/ares/releases {{aresVer}}]|{{✓}} ||{{✓}} ||? ||{{✗}}||{{✓}}||{{✓}}||?

|{{✓}} ||{{✓}} ||{{✓}} ||{{✓}} ||{{✗}} ||{{✓}} <ref group=N name=libretroonly /> ||{{✗}}<ref group=N name=PicoDrive>Only for the 32X as a cross-platform alternative to Kega Fusion.<noncomm /ref>|-|[[FinalBurn Neo]]|align=left|{{Icon|Windows|Linux|macOS}}|[https://github.com/finalburnneo/FBNeo/releases/latest stable] [https://ci.appveyor.com/project/tmaul/fbneo-kbhgd/branch/master WIP builds]|{{✗}} ||{{✗}} ||{{✗}} ||{{✓}} ||{{✗}} ||{{✓}} ||{{✗}}

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|[https://up1standalones.xwikisas.com/#650YS5cXMSc7sGflY1dqeg dev 1.0.02]|{{✓}} ||{{✗}} ||{{✓✗}} ||{{✓}} ||{{✗}} ||{{✓}} ||?

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|MD .emu

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|[https://digiex.net/threads/neogenesis-v25-download-sega-genesis-megadrive-32x-segacd-megacd-emulator.13698 NeoGenesis v25V25]

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;[[Kega Fusion]]:The project of an employee with previous experience at Sega. Kega Fusion has high compatibility, is easy to use , and has plugin-based filter support but it has some issues on newer versions of Windows which can be solved with compatibility settings.;[[PicoDrive]]:Strongly prioritizes performance over accuracy. Compatibility and accuracy isnaren't as good as Genesis Plus GX but it's useful on very underpowered systems like the Raspberry Pi Zero. Currently the first and only cross-platform option for 32X and Pico games.;[[Exodus]]:Think [[bsnes ]], but for the Genesis. Even though higan is also getting into the Genesis game, Exodus has already achieved cycle-accuracy at the familiar cost of high system requirements. It is the newest Genesis emulator and is far from complete.

;[[BlastEm]]:Aims for cycle-accuracy but unlike Exodus, aims for lower system requirements. It has substantially higher compatibility than Exodus, but it should be noted that the last and current official release has inaccurate color emulation.

==Mega Drive Plus / Genesis Plus/ MSU-MD modes==

The Mega Drive Plus / Genesis Plus (sometimes abbreviated as MD+) is a special mode for certain Genesis games that use enhanced CDDA tracks with a Sega CD. This was not used in any official games, however, the mode itself was first used in the first batch of Pier Solar releases. This feature was been [https://downloads.terraonion.com/public/MegaSD_DEV_Manual.pdf documented] to be used on Terraonion's Mega SD flash cartridge, to give similar effects for Genesis games in a way how MSU-1 does in patched SNES games. Another variant was been made for [https://krikzz.com/store/home/59-mega-everdrive-pro.html Mega Everdrive PRO], named as [https://github.com/krikzz/msu-md MSU-MD].

Currently, no only Genesis + Sega CD emulators feature this function, although there is Plus GX supports both modes as mentioned [https://github.com/ekeeke/Genesis-Plus-GX/issues/297 plans to be added#issuecomment-918468508 here] , while Kega Fusion supporting games which can only run in Genesis Plus GXMSU-MD mode.

* [http://wiki.megadrive.org/index.php?title=Main_Page MegaDrive Development Wiki] - A Wiki about every technical aspect of the SEGA MegaDrive hardware and software. Its aim is to provide the most detailed, accurate , and up to date information, to help homebrew development and repairs.