Changes

No$GBA added support for DSi games of all three formats starting with version 2.8, although some games won't boot and others have graphical glitches. You'll need to enable "16MB DSi/retail" under the settings. Emulation is very iffy due to a so-so DS emulation foundation in NONo$GBA, and the camera is just spoofed as a static image but just causes an emulator crash whenever used, meaning games that use it may boot but it won't be very playable.

DSi used an encryption system for the game dumps that went on to be enhanced and used for the 3DS. This encryption is checked at start-up, hence why DS emulators don't even manage to boot DSiWare dumps. It's very unlikely DSi-mode emulation is ever going to be implemented in Desmume DeSmuME in particular due to various ''creative differences'' unique to that project.