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NTVDMx64 can run text-mode DOS applications as well as games such as Doom, but since NTVDMx64 is very slow and uses non-standard ways to run 16-bit applications and games, it is recommended to use emulators such as [[DOSBox]], [[vDOS]] and [[PCem]], virtualization software such as [[VirtualBox]], [[VMware Workstation Player]] and [[QEMU]] etc. to run 16-bit applications and games on 64-bit Windows.
It was tested on the following <b>x64</b> versions of Microsoft Windows:* Windows Server 2003 x64* Windows Server 2008 x64* Windows 7 x64* Windows 8 x64* Windows 8.1 x64* Windows 10 x64* Windows Server 2016 x64* Windows 11 x64
NTVDMx64 was initially incompatible with Windows 11 x64, due to the fact that NTVDMx64 was initially unable to run when Secure Boot is enabled, which is required for Windows 11 x64 to install and run. The author, Leecher1337 added loader support for Windows 11 x64 to NTVDMx64. This also applied to Windows 10 x64, when Secure Boot is enabled.
