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The emulator needs an external virtual drive to read iso files. You'll need to close and restart the emulator (as it says in the Japanese dialogue popup appearing) whenever you modify the options for them to take effect.
Even though it has a "No Bios" option, you'll need
sometimes the bios files, of course specifying the correct region in the options.
F7: Pause and Load State (Press 0-9 to choose)